{"id":3925,"date":"2018-09-05T08:20:19","date_gmt":"2018-09-05T13:20:19","guid":{"rendered":"http:\/\/pharmgate.com\/usa\/?p=3925"},"modified":"2022-12-07T09:42:58","modified_gmt":"2022-12-07T15:42:58","slug":"comparative-study-of-the-efficacy-of-aivlosin-wsg-versus-pulmotil-ac-and-draxxin-25-in-the-control-of-swine-respiratory-disease-srd","status":"publish","type":"post","link":"https:\/\/pharmgate.com\/usa\/news\/comparative-study-of-the-efficacy-of-aivlosin-wsg-versus-pulmotil-ac-and-draxxin-25-in-the-control-of-swine-respiratory-disease-srd\/","title":{"rendered":"Comparative study of the efficacy of Aivlosin\u00ae<\/sup> WSG versus Pulmotil\u00ae<\/sup> AC and Draxxin\u00ae<\/sup> 25 in the control of Swine Respiratory Disease (SRD)"},"content":{"rendered":"

Lechtenberg, K.F.1<\/sup>, Lopez, A2<\/sup>, Berge, A.C.3<\/sup>, Mora, J.2<\/sup>, Hintz, A. 4<\/sup><\/p>\n

1 <\/sup>Midwest Veterinary Services, Nebraska, U.S.; 2 <\/sup>ECO Animal Health, Ltd., London, United Kingdom; 3 <\/sup>Berge Veterinary Consulting, Vollezele, Belgium; 4<\/sup> Pharmgate Animal Health, Wilmington, North Carolina, U.S.<\/p>\n

 <\/p>\n

The objective of this study was to compare the effectiveness of Aivlosin\u00ae<\/sup> 62.5% Water Soluble Granules (WSG), Pulmotil\u00ae<\/sup> AC and Draxxin\u00ae<\/sup> 25 for the control of SRD in 216 naturally infected pigs.<\/p>\n

 <\/p>\n

Material and Methods<\/strong><\/p>\n

On Day 0, when approximately 5% of pigs showed clinical signs of SRD, pigs were randomly allocated to Aivlosin\u00ae<\/sup>, Pulmotil\u00ae<\/sup>, Draxxin\u00ae<\/sup> or untreated Control groups. Each group consisted of 54 pigs housed in 9 pens. The Aivlosin\u00ae<\/sup> and Pulmotil\u00ae <\/sup>pigs received medicated water for 5\u00a0consecutive days (D1-D5) at inclusion rates of 50 ppm tylvalosin and 200 ppm tilmicosin, respectively. The Draxxin\u00ae<\/sup> pigs received a single injection of Draxxin\u00ae<\/sup> at 2.5 mg\/kg bodyweight (D1). The Control and Draxxin\u00ae<\/sup> pigs received unmedicated water throughout the study.<\/p>\n

Clinical observations were performed daily from D0-D5. The primary variables for efficacy comparison were pen clinical score (sum of respiratory and depression scores on a scale of 0 (normal) to 3 (severe)) and mortality. Average daily gain (ADG) and feed conversion rate (FCR) were secondary variables and analysed with general linear models controlling for bodyweight (including pigs that died) on D0. Clinical score data was analysed with a cumulative logistic regression model of pig nested within pen, and accounting for the D0 scores.<\/p>\n

Results<\/strong><\/p>\n

All three treatments significantly reduced the clinical scores compared to the Control group (Table 1). \u00a0Aivlosin\u00ae was not significantly different to Draxxin\u00ae for clinical scores (OR=1.20;P=0.54). The odds of a higher clinical score were significantly higher in Pulmotil\u00ae compared to Draxxin\u00ae (OR=2.26;P<0.01) and Aivlosin\u00ae (OR=0.53;P=0.03) groups. Mortality was numerically lowest in the Aivlosin\u00ae group (Table 1).<\/p>\n

 <\/p>\n

Table 1: Summary of Analysis of Clinical Score Data (Frequency) (D0-D5) and Mortality<\/strong><\/p>\n\n\n\n\n\n\n\n
<\/td>\nScore<\/strong><\/p>\n

0<\/strong><\/td>\n

Score <\/strong><\/p>\n

1<\/strong><\/td>\n

Score <\/strong><\/p>\n

2<\/strong><\/td>\n

Score <\/strong><\/p>\n

3<\/strong><\/td>\n

Score<\/strong><\/p>\n

4<\/strong><\/td>\n

Score<\/strong><\/p>\n

5<\/strong><\/td>\n

Score<\/strong><\/p>\n

6<\/strong><\/td>\n

P-diff*<\/strong><\/td>\n\u00a0<\/strong><\/td>\nMortality (%)<\/strong><\/td>\n<\/tr>\n
Aivlosin\u00ae<\/sup><\/strong><\/td>\n136<\/td>\n38<\/td>\n70<\/td>\n13<\/td>\n13<\/td>\n0<\/td>\n0<\/td>\nc<\/td>\n<\/td>\n0<\/td>\n<\/tr>\n
Pulmotil\u00ae<\/sup><\/strong><\/td>\n114<\/td>\n44<\/td>\n71<\/td>\n18<\/td>\n13<\/td>\n0<\/td>\n1<\/td>\nb<\/td>\n<\/td>\n7<\/td>\n<\/tr>\n
Draxxin\u00ae<\/sup><\/strong><\/td>\n161<\/td>\n40<\/td>\n50<\/td>\n12<\/td>\n7<\/td>\n0<\/td>\n0<\/td>\nc<\/td>\n<\/td>\n2<\/td>\n<\/tr>\n
Control <\/strong><\/td>\n59<\/td>\n56<\/td>\n75<\/td>\n33<\/td>\n43<\/td>\n1<\/td>\n<\/td>\na<\/td>\n<\/td>\n7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*P values generated from regression model; different letter shows significant difference (P<0.05)<\/p>\n

The Draxxin\u00ae group had significantly higher ADG than the other groups; FCR was significantly lower in the Aivlosin\u00ae than the Pulmotil\u00ae and Control groups (Table 2).<\/p>\n

 <\/p>\n

Table 2: ADG and FCR (Pounds) D0-D6<\/strong><\/p>\n\n\n\n\n\n
<\/td>\nAivlosin\u00ae<\/strong><\/td>\nPulmotil\u00ae<\/strong><\/td>\nDraxxin\u00ae<\/strong><\/td>\nControl<\/strong><\/td>\n<\/tr>\n
ADG <\/strong><\/td>\n0.50b<\/sup><\/td>\n0.50b<\/sup><\/td>\n0.65a<\/sup><\/td>\n0.47b<\/sup><\/td>\n<\/tr>\n
FCR <\/strong><\/td>\n1.03b<\/sup><\/td>\n1.08ab<\/sup><\/td>\n0.96b<\/sup><\/td>\n1.26a<\/sup><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Conclusions<\/strong><\/p>\n

The Aivlosin\u00ae group had significantly better SRD clinical scores during the treatment period than Pulmotil\u00ae or Control groups and no significant difference to the Draxxin\u00ae group. Mortality was lowest in the Aivlosin\u00ae<\/sup> group. FCR was significantly lower in the Aivlosin\u00ae compared to the Pulmotil\u00ae and Control groups.<\/p>\n

\u00aeAivlosin is a registered trademark of ECO Animal Health Ltd., London, United Kingdom<\/p>\n

\u00aeDraxxin is a registered trademark of Zoetis Inc., U.S.A.<\/p>\n

\u00aePulmotil is a registered trademark of Elanco Inc., U.S.A.<\/p>\n","protected":false},"excerpt":{"rendered":"

Lechtenberg, K.F.1, Lopez, A2, Berge, A.C.3, Mora, J.2, Hintz, A. 4 1 Midwest Veterinary Services, Nebraska, U.S.; 2 ECO Animal Health, Ltd., London, United Kingdom;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[127],"product":[],"active_ingredient":[],"species_vfd":[],"indication":[],"blue_bird_label":[],"watersolutions":[],"post-category":[186],"class_list":["post-3925","post","type-post","status-publish","format-standard","hentry","category-news","post-category-research"],"acf":[],"yoast_head":"\nComparative study of the efficacy of Aivlosin\u00ae WSG versus Pulmotil\u00ae AC and Draxxin\u00ae 25 in the control of Swine Respiratory Disease (SRD) - USA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharmgate.com\/usa\/news\/comparative-study-of-the-efficacy-of-aivlosin-wsg-versus-pulmotil-ac-and-draxxin-25-in-the-control-of-swine-respiratory-disease-srd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparative study of the efficacy of Aivlosin\u00ae WSG versus Pulmotil\u00ae AC and Draxxin\u00ae 25 in the control of Swine Respiratory Disease (SRD) - USA\" \/>\n<meta property=\"og:description\" content=\"Lechtenberg, K.F.1, Lopez, A2, Berge, A.C.3, Mora, J.2, Hintz, A. 4 1 Midwest Veterinary Services, Nebraska, U.S.; 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